Researchers' discovery may lead to hypertension treatment

Researchers' discovery may lead to hypertension treatment: "Frank Schroeder, an assistant scientist at BTI and co-author of the paper, which appeared in a recent issue of Proceedings of the National Academy of Sciences, developed a new technique for analyzing complex mixtures of small molecules, making it possible to finally identify the hormone. Prior to the discovery, researchers knew that a human steroid called aldosterone activates the kidney to reabsorb sodium and excrete potassium, which led them to suspect that there must be another hormone that would trigger the kidney to do the opposite: excrete sodium and reabsorb potassium. Many had tried to find such a hormone in human urine, but urine contains a mix of hundreds of molecules, and the correct one could not be isolated, probably because the suspected hormone breaks down easily during traditional chemical analysis. Most researchers had given up searching for this 'holy grail' of kidney hormones, until, in 2003, a private company, Naturon Corp., contacted Schroeder, then a research associate at Cornell and Harvard Medical School. To do the job, Schroeder developed an approach based on nuclear magnetic resonance (NMR) spectroscopy of partially purified urine. Traditionally, NMR spectroscopy, arguably the most powerful tool chemists use to determine the structures of unknown compounds, has only been used for the analysis of p"