DNA Template Could Explain Evolutionary Shifts: "In this newer report, Lupski and colleagues describe how this process – called fork stalling and template switching (FoSTeS) in humans or microhomology-mediated break-induced replication (MMBIR) in simpler models – generated genomic rearrangements ranging in size from several megabases to a few hundred base pair during normal cell division, resulting in the duplication or even triplications of individual genes or the rearrangements of single exons (the coding region of genes).
'This phenomenon occurs throughout the genome,' said Dr. Feng Zhang, a postdoctoral associate in Lupski's laboratory and the first author of the report."
Monday, June 22, 2009
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