Friday, August 21, 2009
The ends of mRNAs may prevent the beginnings of cancer | Eureka! Science News:
"'So now, in the cancer cell, the same protein is being made, but a lot of regulatory sequences have been lost,' says Mayr. 'And in the beginning, I had no idea what this means. But then I found that those shorter mRNAs were making much more protein. ....So, my theory is that in normal cells, genes are tightly regulated by their long 3'UTRs,' says Mayr. 'And the cancer cell somehow has the ability to express the shorter mRNA without those regulatory sequences. Without that regulation, it's able to express large quantities of protein.'"
Not totally a surprise but if this happens in cancer, where else does it happen?
Posted by SM Schwartz at 8:27 AM